Journal: bioRxiv
Article Title: Splenic tropism of Plasmodium vivax in acute infection and spleen-attenuated systemic inflammation
doi: 10.64898/2026.03.25.714340
Figure Lengend Snippet: Comparison of plasma concentrations of A) CFHb, B) IL-6, C) TNF-alpha, D) ang-2, E) IL1-beta, F) IL-18 and G) IL-10 in spleen-intact (spleen) and splenectomized individuals (No spleen, n=25) with acute uncomplicated vivax malaria in Timika, Indonesia. Data points are individual patients with median and interquartile range shown. All measurements in the spleen-intact group were from cohort 1 (n=24), except CFHb (cohort 2, n=36). Measurements below the detection limit of each marker were assigned a value of half the lower limit of detection of the assay, comprising of the following number of patients: 3 TNF-alpha and 2 IL-10 in the spleen-intact group, and 2 TNF-alpha, 7 IL-1b, 1 IL-18 and 2 IL-10 in the splenectomized group. The Mann-Whitney U test was used for statistical comparison. Abbreviations: CFHb, cell-free hemoglobin; IL-6, interleukin-6, TNF-alpha, tumour necrosis factor-alpha; ang-2, angiopoietin-2; IL-1b, interleukin-1 beta; IL-18, interleukin-18; IL-10, interleukin-10.
Article Snippet: Plasma levels of the endothelial activation marker, angiopoietin-2 (ang-2), and the pro-inflammatory cytokine, interleukin-6 (IL-6), were determined using the QuantikineTM ELISA Human Ang-2 and Human IL-6 Immunoassays from R&D Systems (Bio-Techne, US).
Techniques: Comparison, Clinical Proteomics, Marker, MANN-WHITNEY